Supportive Oligonucleotide Therapy (SOT) for Lyme

SOT is a cutting-edge treatment for infections, including Borrelia Burgdorferi. This article serves to educate and help you decide if it may be right for you.



Supportive Oligonucleotide Therapy (SOT) is a new treatment for Lyme disease. SOT is also called Antisense Oligonucleotide Therapy (ASOT), which is the term used in medical research papers. SOT uses laboratory-derived nucleic acids (genetic code) that block the production of disease-causing proteins or even gene expression.

Essentially, SOT is the creation of a shutoff “key” that precisely fits a chosen “lock” portion of a cancer cell or pathogen. The “lock” is a specific section of DNA that normally controls an important function of the cancer cell or pathogen. The “key” binds to the “lock” and blocks the function thus killing the cancer cell or pathogen. After they die off, the SOT compound is released and travels to the next target, thus fighting cancer or infection 24/7 for months.

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How Does It Work?

A patient’s blood is drawn to obtain circulating tumor cells, viruses, or Lyme bacteria. The blood is sent to a lab such as RGCC and the SOT is created. The SOT is infused intravenously in a doctor’s office. Intravenous antihistamines and steroids are given immediately prior to SOT administration in order to lower the chance of an allergic reaction and tighten the vein walls to minimize the leaking of SOT. The SOT may be repeated up to 3x per year as needed. With each round of SOT, it is recommended to again test for the presence of pathogens. At some point, the infection may be completely eradicated or remain stable in quiet remission.

SOT has the ability to induce apoptosis (cell death). From a blood sample, the CTCs are identified then a small molecule called microRNA is developed to match exactly into a “lock” portion of the cancer cell that controls vital cell functions. The SOT is injected intravenously, spreads throughout the body including past the blood-brain barrier, embeds into the Lyme bacteria, and will disrupt its ability to replicate. SOT has a stealth-like ability to avoid destruction by the immune system and existing bacteria.

Frequently Asked Questions

  • What labs do I need for a SOT? Any positive test for Lyme or co-infections within 6 months of ordering the SOT is valid.
  • How long does it last? SOT continues to fight Lyme disease for 3 to 6 months
  • How many times can you do SOT? Up to three times per year
  • What are some potential side effects? Lyme patients may experience Herx or detox reactions such as fatigue, body aches, and headaches.
  • How much does it cost? Costs may vary, but it typically ranges from $1,500 to $5,000 depending on where you go, how often you treat, and the experience of your provider.
  • What are some potential problems? SOT needs to target each type of infection that a person may be infected with. So it is very doubtful one infusion of SOT will reach all co-infections such as Bartonella or Babesia meaning you will likely require multiple rounds to achieve results.

How Do You Choose A SOT Clinic?

When picking a SOT Clinic there are multiple questions you should ask yourself:

  1. Are they a certified IV center and for how long?
  2. How long have they been doing SOT for cancer?
  3. How many patients have they administered the Lyme (EBV, Co-infections), SOT, to?

List of SOT Clinics

The list provided below is copied from a SOT Facebook group and does not represent the opinions of Project Lyme. We always recommend you do sufficient research prior to choosing a therapy or clinic.