Prevent Lyme and Tick-Borne Disease by Targeting Tick-Carrying Mice

By Alexis Chesney ND


Control the tick population in your home landscape – and prevent Lyme disease – by addressing the animals that act as hosts to ticks. Disease-carrying ticks are found in all 50 states in the U.S. and, as their numbers rise and their ranges increase, so, too, do cases of tick-borne illnesses.

As Richard Ostfeld explains, “White footed mice are consistently shown to be the most efficient wildlife reservoirs of Borrelia burgdorferi, infecting between 75 and 95 percent of larval blacklegged ticks that feed on them.” Wood piles, brush piles, compost piles, stone walls, and rotting wood will attract mice. Eliminating or limiting these areas is a key step.

Tick tubes are an excellent intervention to target ticks in areas where mice nest, and will help in your quest to prevent Lyme disease and protect yourself, your family, and your pets.

Place these biodegradable cardboard tubes filled with permethrin-treated cotton in areas where mice are found. The mice will take the permethrin-treated cotton to build their nests. The permethrin will not harm the mice or other animals, but it will kill ticks and, most important, at the larval stage. It is important to note that permethrin can be toxic for cats, especially in concentrated doses. Cats are more sensitive to permethrin than other mammals, but cat lovers can still use the insecticide as long they’re careful about it, veterinarians say.

It is the larvae that most often feed on mice, and the permethrin kills them before they have a chance to acquire pathogens from the mice and before they reach the nymph and adult stages, when they might use humans as hosts. Research shows that over an 8-year period, there was on average a 93.6 percent reduction in exposure per hour to infected ticks in treated areas of the Fire Island Pines, New York.

I hear reports of successful tick reduction from patients of mine who have treated their land with tick tubes. After applying tick tubes, many people have shared that they went from finding many ticks one year to finding few or no ticks on their property the next year.

You can purchase tick tubes from farm stores and online (see a list of resources in Preventing Lyme). You can also make your own tick tubes (directions below).

Set out the tick tubes in early spring, midsummer, and early fall to target the surges in tick numbers as a result of the tick life cycle. Use six tick tubes per 1/8 acre of mouse habitat. To calculate mouse habitat, do not include buildings, paved areas, or lawn. Place the tubes in mouse habitat: wood piles, stone walls, near compost, around the perimeter of structures like a shed, under bushes, and in gardens. If possible, place the tubes in places that would stay dry when it rains. Space the tubes 30 feet away from each other. You may replace the tubes when you notice they are empty. If you notice that tubes are remaining full, consider moving them a few inches or feet in one direction or another to improve the potential for mice to find them.

Make Your Own Tick Tubes

You Will Need

  • Permethrin (available at sporting goods stores, farm stores, and so on); it comes in spray form or as a concentrated liquid
  • Spray bottle (if your permethrin solution is not already in a spray bottle)
  • Cotton balls, old cotton batting from cushions or pillows, even old dryer lint — any fluffy natural material that will degrade over time
  • Gloves and a mask
  • Cardboard box
  • Cardboard tubes from toilet paper or paper towel rolls


  • If you’re working with concentrated permethrin, dilute it, following the instructions on the packaging, and pour it into a spray bottle.
  • Put on your gloves and mask.
  • Lay out the cotton or lint in the box. Set the box in a well-ventilated area.

  • Spray the cotton or lint with the permethrin, soaking it thoroughly. Flip it over and spray the other side.
  • Let the cotton or lint dry for a few hours.

  • Stuff the permethrin-treated cotton or lint into the cardboard tubes, leaving the last inch or so of the ends empty.

Note: Keep the permethrin away from your skin and pets while wet. It is safe to touch once dried. And remember that permethrin is toxic to bumblebees, butterflies, and aquatic life; be sure that when you are spraying the permethrin, the spray will not drift onto any nearby plants or into waterways. The permethrin does not cause an environmental concern because it binds tightly with the fiber in the tubes. If for some reason permethrin did come into contact with soil, it degrades quickly, so it will not seep into groundwater.

Portions of the above article are excerpted from Preventing Lyme & Other Tick-Borne Diseases © Alexis Chesney. Illustrations © Beverly Duncan.

Alexis Chesney ND, LAc is a naturopathic physician and acupuncturist specializing in the treatment of Lyme and other tick-borne diseases. She works with patients at the integrative non-profit Sojourns Community Health Clinic in Westminster, Vermont, and has a private telehealth practice. Dr. Chesney serves as a preceptor for the ILADEF Physician Training Program. She is the author of Preventing Lyme and Other Tick-Borne Diseases released through Storey Publishing and speaks on tick-borne diseases at conferences and in the media. She may be found at